Fascin (D1A8) Rabbit mAb
货号：
9269S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 9269S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Fascin (D1A8) Rabbit mAb recognizes endogenous levels of total fascin protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Fascin is a monomeric, globular protein that plays a central role in regulating the structure and function of the cortical actin cytoskeleton (1). Fascin promotes cross-linkage of parallel actin filaments during the formation of cell protrusions (lamellipodia and filopodia), and therefore plays an important role in regulating cell migration (2). It has been reported that fascin may also regulate filopodia formation by a mechanism independent of its actin-bundling functions (3), though less is known about this mechanism of action. Research studies have shown that increased fascin expression is associated with increased motility and invasiveness of neoplastic cells, including breast, colon, prostate, and esophageal squamous cell carcinomas (4-6). Fascin binds to the armadillo-repeat domain of β-catenin in vitro and in vivo, and has been shown to co-localize with β-catenin and cadherins at the leading edge of migratory cells (7). |
| 存放说明 | -20C |
| 计算分子量 | 54 |
参考图片Western blot analysis of extracts from various cell lines using Fascin (D1A8) Rabbit mAb.使用Fascin (D1A8) Rabbit mAb对多种细胞提取物进行western blot分析。 |
