| 货号 | 4268S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | Fer (5D2) Mouse mAb detects endogenous levels of total Fer protein. This antibody does not cross-react with other related proteins. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 背景 | Fer is a nonreceptor protein-tyrosine kinase of the Fes/Fps family. Like many other cytoplasmic tyrosine kinases, Fer contains a long amino-terminal domain, a central SH2 domain, and a carboxy-terminal kinase domain. Its amino-terminal domain is responsible for protein oligomerization as well as interaction with cytoskeletal proteins. Fer is ubiquitously expressed in a wide variety of cell and tissue types, and is localized to both cytoplasm and nucleus (1). Tyrosine kinase activity of Fer can be stimulated by growth factors and cytokines (2,3). After activation, Fer can further activate various downstream signaling components including Stat3 (3). Fer plays an important role in regulation of cell movement, oncogenesis and inflammation (4). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
Western blot analysis of extracts from NIH/3T3, A549 and SK-MEL-5 cells using Fer (5D2) Mouse mAb. 使用Fer (5D2) Mouse mAb，免疫印迹（Western Blot）分析NIH/3T3、A549和SK-MEL-5细胞中Fer (5D2)蛋白水平。 |
