FGF Receptor 3 (C51F2) Rabbit mAb【科瑞奥博】

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FGF Receptor 3 (C51F2) Rabbit mAb

货号： 4574S 基本售价： 3360.0 元规格： 100ul

产品信息

概述
货号	4574S
反应种属	Human
来源宿主	Rabbit
应用	W/IP/IHC-P/IF-IC
目标/特异性	FGF Receptor 3 (C51F2) Rabbit mAb detects endogenous levels of FGF Receptor 3 protein. This antibody does not cross-react with other related family members.
使用方法	WB(1:1000) IP (1:50) IHC-P (1:50) IF-IC (1:200)

性能
供应商	CST
背景	Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3, and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5).
存放说明	-20C
计算分子量	165, 145 and 125

参考图片

Western blot analysis of recombinant human FGFR-3 cytoplasmic fragment proteins (lane 1) and extracts from KMS-11 cells (lane 2) using FGF Receptor 3 (C51F2) Rabbit mAb.Western blot检测重组人FGFR-3胞内段蛋白片段（第一道）和KMS-11细胞的提取物。使用的抗体为：FGF Receptor 3 (C51F2) Rabbit mAb。

Immunohistochemical analysis of paraffin-embedded KMS-11 cells, using FGF Receptor 3 (C51F2) Rabbit mAb.免疫组化检测石蜡包埋的KMS-11细胞，使用的抗体为 FGF Receptor 3 (C51F2) Rabbit mAb.

Immunohistochemical analysis of paraffin-embedded small cell lung carcinoma, using FGF Receptor 3 (C51F2) Rabbit mAb.免疫组化检测石蜡包埋的非小细胞型肺癌组织，使用的抗体为 FGF Receptor 3 (C51F2) Rabbit mAb。

Confocal immunofluorescent analysis of KMS-11 (left) and RPMI-8226 cells (right) using FGF Receptor 3 (C51F12) Rabbit mAb (green). Blue pseudocolor= DRAQ5® #4084 (fluorescent DNA dye).激光共聚焦荧光法检测KMS-11 (左)和RPMI-8226（右）细胞，使用抗体为：FGF Receptor 3 (C51F12) Rabbit mAb（绿色）。蓝色伪彩为DNA荧光染料（产品信息为 DRAQ5®#4084 ）。