Filamin B (D7E4W) Rabbit mAb
货号：
12979S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12979S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | <p>Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (α-actinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as β-integrins, Rho/Rac/Cdc42, PKC and the insulin receptor, primarily through the carboxy-terminal dimerization domain (1-3). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Filamin A is phosphorylated by PAK1 at Ser2152, which is required for PAK1-mediated actin cytoskeleton reorganization (4).</p>Filamins是一类二聚体actin结合蛋白，可以作为细胞黏附位点的组成部分。它们也作为折叠蛋白成为信号分子的亚细胞靶点（1）。Actin结合结构域（alpha-actinin）位于氨基末端，后面接着是96个氨基酸残基组成的24个串联重复序列，二聚体结构域位于羧基端。除了actin 微丝，Filamin也可以和其他结构和信号分子，例如beta整合素，Rho/Rac/Cdc42, PKC,和胰岛素受体，通过羧基端二聚体结构域结合（1-3）。Filamin A，表达丰度最高，和Filamin B都是广泛表达的亚型，Filamin C主要表达在肌肉中（1）。Filamin A能被PAK1在2152位丝氨酸磷酸化，这对PAK1介导的actin细胞骨架重构是必须的（4）。 |
| 存放说明 | -20C |
| 计算分子量 | 280 |
参考图片Western blot analysis of extracts from various cell types using Filamin B (D7E4W) Rabbit mAb. 使用Filamin B (D7E4W) Rabbit mAb对多种细胞提取物进行western blot分析。 |
