GADD45 alpha (D17E8) Rabbit mAb
货号:
4632S 基本售价:
3360.0 元 规格:
-
产品信息
概述货号 | 4632S |
反应种属 | Human/Mouse/Rat/Monkey |
来源宿主 | Rabbit |
应用 | W |
使用方法 | WB(1:1000) |
性能供应商 | CST |
背景 | GADD45 α, β and γ are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage. GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents (1). GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase (2). GADD45 forms a complex with p21 and Cdc2, and may serve as core for interaction with other cell cycle regulators (3,4).GADD45 α, β 和 γ是进化上保守的核蛋白同源家族,在细胞生理和环境损伤过程中作为应激传感器发挥作用。GADD45蛋白参与紫外辐射或烷化剂诱导的G2/M期检验点激活(1)。GADD45诱导G2/M期检验点通过Cdc2-周期蛋白 B1激酶的失活来调节(2)。GADD45与p21以及Cdc2形成复合体,并可作为其它细胞周期调节子相互作用的核心(3,4)。 |
存放说明 | -20C |
计算分子量 | 22 |
参考图片Western blot analysis of extracts from various cell lines and tissues using GADD45 alpha (D17E8) Rabbit mAb.western blot方法检测不同细胞和组织提取物,使用的抗体为GADD45 alpha (D17E8) Rabbit mAb。 |