| 货号 | 12953S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:600) |
| 供应商 | CST |
| 背景 | <p>Gelsolin (actin-depolymerizing factor, ADF, AGEL, Brevin) is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin (1,2). Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca<sup>2+</sup>-dependent manner (3,4). Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling (3). Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation (5,6). In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition (7).</p> Gelsolin (actin-解聚因子, ADF, AGEL, Brevin) 是一个83kDa蛋白与villin和adseverin/scinderin具有结构和功能同源性（1,2）。Gelsolin在Ca<sup>2+</sup>依赖的形式下加帽并切断actin蛋白从而在actin的聚合过程中发挥了重要作用(3,4).Gelsolin对细胞骨架所需要的细胞活动（例如，胞膜边缘波动，趋药性，纤毛形成）是非常重要的(3).相应地，gelsolin敲除的小鼠细胞会表现出运动性缺陷，包括无法对生长因子刺激发生波动反应（5,6）。人体的gelsolin缺陷与amyloidosis type 5 (AMYL5)相关，一种颅神经病变为特征的遗传性疾病，该疾病看起来是由于gelsolin淀粉样蛋白沉积所引起的（7）。 |
| 存放说明 | -20C |
| 计算分子量 | 83 |
Western blot analysis of extracts from various cell lines using Gelsolin (D9W8Y) Rabbit mAb.使用Gelsolin (D9W8Y) Rabbit mAb对多种细胞提取物进行western blot分析。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Gelsolin (D9W8Y) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right).在对照肽（左）和抗原特异性肽段（右）存在的前提下，使用Gelsolin (D9W8Y) Rabbit mAb对石蜡包埋的人乳腺癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using Gelsolin (D9W8Y) Rabbit mAb.使用Gelsolin (D9W8Y) Rabbit mAb对石蜡包埋的人结肠癌组织进行免疫组化分析。 |
