GFAT2 (D40C7) Rabbit mAb
货号：
6917S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6917S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | GFAT2 (D40C7) Rabbit mAb recognizes endogenous levels of total GFAT2 protein. This antibody also cross-reacts with GFAT1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | GFAT1, glutamine:fructose-6-phosphate aminotransferase 1, is the rate-limiting enzyme of the hexosamine biosynthesis pathway (1). This enzyme catalyzes the conversion of fructose-6-phosphate and glutamine to glucosamine-6-phosphate and glutamate (2). The hexosamine biosynthesis pathway generates the building blocks for protein and lipid glycosylation (2). Furthermore, studies suggest that increased activity of this pathway is a contributing factor to hyperglycemia-induced insulin resistance (1,2). GFAT1 is more active in non-insulin-dependent diabetes mellitus (NIDDM) patients (3). Transgenice mice overexpressing this enzyme in skeletal muscle and adipose tissue show an insulin resistance phenotype (4,5). GFAT2, an isoenzyme of GFAT1, was later identified (6, 7). Studies show that the regulation of GFAT2 is different from that of GFAT1, suggesting differential regulation of the hexosamine pathway in different tissues (7). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
参考图片Western blot analysis of extracts from U251 cells using GFAT2 (D40C7) Rabbit mAb. Wetern blot检测 U251 细胞提取物，所用抗体为GFAT2 (D40C7) Rabbit mAb兔单抗。 |
