Glut4 (1F8) Mouse mAb
货号：
2213S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2213S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | Glut4 (1F8) Mouse mAb detects endogenous levels of total Glut4 protein. It does not cross-react with other related proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | A group of related glucose transporters (Glut1-5 and 7) mediate the facilitated diffusion of glucose in nonepithelial mammalian tissues. Within insulin-responsive tissues such as muscle and fat, Glut1 contributes to basal glucose uptake while Glut4 is responsible for insulin-stimulated glucose transport (1-3). Glut4 is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation (1,2,4). Translocation of Glut4 is dependent on Akt, which may act by phosphorylating AS160, a RabGAP protein involved in membrane trafficking (5). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
参考图片Western blot analysis of extracts from NIH/3T3 cells using Glut4 (1F8) Mouse mAb. 对NIH/3T3细胞抽提液使用Glut4 (1F8) Mouse mAb鼠单抗进行Western blot分析。 |
