GOPC (D10A12) Rabbit mAb
货号：
8576S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8576S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | GOPC (D10A12) Rabbit mAb detects endogeneous levels of total GOPC protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | GOPC (FIG) was originally identified as a Golgi-associated, PDZ domain containing protein. It has two coiled-coil domains (CC1 and CC2) located in the amino-terminal region and a PDZ domain in the carboxy-terminal region (1). The CC2 domain and its adjacent linker region mediate the association of GOPC with the golgi protein golgin-160 and the Q-SNARE protein syntaxin 6 (1,2). The PDZ domain of GOPC interacts with the carboxy terminus of target proteins to mediate target protein vesicular trafficking and surface expression (3-6). Fusion of the corresponding GOPC gene with the ROS tyrosine kinase oncogene has been detected in some glioblastomas. The resulting GOPC-ROS fusion protein is targeted to the golgi apparatus where a constitutively activate ROS tyrosine kinase can mediate tumor formation (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 59 |
参考图片Western blot analysis of extracts from various cell lines using GOPC (D10A12) Rabbit mAb. 对多个细胞系使用GOPC (D10A12) Rabbit mAb兔单抗进行Western blot分析。 |
