| 货号 | 3369S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Mouse |
| 应用 | W/IHC-P/IF-IC |
| 目标/特异性 | GSTP1 (3F2) Mouse mAb detects endogenous levels of total GSTP1 protein. The antibody does not cross react with GST-tagged proteins. |
| 使用方法 | WB(1:1000) IHC-P (1:800) IF-IC (1:100) |
| 供应商 | CST |
| 背景 | Glutathione S-transferases (GSTs) are a family of isoenzymes that detoxify electrophiles through conjugation to thiol-reduced glutathione (GSH). Thus, they are critical in protecting cells from toxins (drugs, pesticides, carcinogens) and oxidative stress (1). Eight isoforms of cytosolic-soluble GSTs (α, κ, μ, π, σ, θ, ζ, and ω) are identified, while only GST-α, -μ, and -π are described in the central nervous system (2). GSTP1 (GSTπ) is overexpressed in early stages of carcinogenesis and can be used as a neoplastic marker in tumor tissues (3). GSTP1 directly inhibits TRAF2 and JNK but not NF-κB (4,5). Corresponding GSTP1 gene polymorphisms affect substrate selectivity and stability, and the oxidative milieu in dopaminergic neurons, which increases the susceptibility to Parkinson’s disease (6). |
| 存放说明 | -20C |
| 计算分子量 | 23 |
Western blot analysis of extracts from PC3 cells and human cerebellum using GSTP1 (3F2) Mouse mAb. Western blot分析PC3细胞和人小脑提取物，使用的抗体是GSTP1 (3F2) Mouse mAb 鼠单抗。 | |
Confocal immunofluorescent analysis of PC3 cells using GSTP1 (3F2) Mouse mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). 共聚焦免疫荧光分析PC3细胞，使用的抗体是GSTP1 (3F2) Mouse mAb 鼠单抗（绿色）。肌动蛋白用DY-554 phalloidin（红色）标记。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using GSTP1 (3F2) Mouse mAb. 免疫组化分析石蜡包埋的人肺癌，使用的抗体是GSTP1 (3F2) Mouse mAb 鼠单抗。 | |
Immunohistochemical analysis of paraffin-embedded human lymphoma using GSTP1 (3F2) Mouse mAb. 免疫组化分析石蜡包埋的人淋巴瘤，使用的抗体是GSTP1 (3F2) Mouse mAb 鼠单抗。 |
