HER3/ErbB3 (1B2E) Rabbit mAb
货号：
4754S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4754S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | HER3/ErbB3 (1B2) Rabbit mAb detects endogenous levels of total HER3/ErbB3 proteins. This antibody does not cross-react with other ErbB family members. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase (1,2). There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2, and the p85 subunit of PI3 kinase, which mediate ErbB downstream signaling (3). Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3 kinase (4).
ErbB3 is highly expressed in many cancer cells (5) and activation of the ErbB3/PI3K pathway is correlated with malignant phenotypes of adenocarcinomas (6). In tumor development, ErbB3 may function as an oncogenic unit together with other ErbB members (e.g. ErbB2 requires ErbB3 to drive breast tumor cell proliferation) (7). Thus, inhibiting interaction between ErbB3 and ErbB tyrosine kinases has become a novel strategy for anti-tumor therapy. |
| 存放说明 | -20C |
| 计算分子量 | 185 |
参考图片Western blot analysis of MCF7 and T47D cell lysates, using HER3/ErbB3 (1B2) Rabbit mAb.Western blot法检测MCF7 和T47D细胞的裂解液，使用抗体为：HER3/ErbB3 (1B2) Rabbit mAb。 |
