HIF-2α (D9E3) Rabbit mAb
货号：
7096S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 7096S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | HIF-2α (D9E3) Rabbit mAb recognizes endogenous levels of total HIF-2α protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Hypoxia-inducible factor (HIF) is essential for the cellular response to hypoxia (1,2). Under normoxia conditions, the α subunit of HIF is ubiquitinated by von Hippel-Lindau (VHL) protein and is degraded in the ubiquitin/proteasome pathway (1,2). Hypoxia inhibits the degradation of the α subunit, which leads to its stabilization (1,2). HIF, in turn, regulates the transcription of a variety of genes that respond to hypoxia conditions (1,2). There are several isoforms of the HIF α subunit (2). Studies have found that HIF-1α and HIF-2α expression is increased in some human cancers (2). HIF-1α has both pro- and anti-proliferative activities, whereas HIF-2α does not possess anti-proliferative activity (2). Therefore, HIF-2α likely plays an important role in tumorigenesis (2,3). |
| 存放说明 | -20C |
| 计算分子量 | 120 |
参考图片Western blot analysis of Hep G2 cells, untreated (-) or treated with cobalt chloride (CoCl2, 0.1 mM, 4 hr, +) using HIF-2α (D9E3) Rabbit mAb (upper) or β-Actin Antibody #4967 (lower).未处理（-）或使用氯化钴（CoCl2, 0.1 mM, 4 小时, +) ）处理后的HepG2细胞，使用HIF-2α (D9E3)兔单抗（上）或β-Actin 抗体#4967（下）进行western blot。 |
