HSPA8 (D12F2) Rabbit mAb
货号：
8444S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8444S |
| 反应种属 | Human/Mouse/Rat/Monkey/Bovine/Pig |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | HSPA8 (D12F2) Rabbit mAb recognizes endogenous levels of total HSPA8 protein. This antibody cross-reacts with HSPA2 and HSPA1A. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | HSPA8, alternately known as HSC70 or HSP73, is a constitutively expressed member of the HSP70 superfamily (1). Although its primary role in cells appears to be that of a general chaperone for unfolded proteins, HSPA8 has also been identified as the uncoating ATPase responsible for removing clathrin from coated vesicles and may also play a role in stabilizing untranslated mRNAs (1-5). In addition to these "housekeeping" functions, HSPA8 may also have an important role in inducible cellular stress responses. For example, oxidative or thermal stress promotes the nuclear/nucleolar accumulation of HSPA8, where it forms a complex with the topoisomerase I complex and likely protects it from heat inactivation (6,7). HSPA8 is reportedly phosphorylated in response to DNA damage, but it reamins unclear what effect, if any, this has on HSPA8 function (8-10). Numerous high throughput studies support this observation. For more information, please see the HSPA8 page in PhosphoSitePlus® at www.phosphosite.org. |
| 存放说明 | -20C |
| 计算分子量 | 70-72 |
参考图片Western blot analysis of extracts from various cell lines using HSPA8 (D12F2) Rabbit mAb. 对多个细胞系使用HSPA8 (D12F2) Rabbit mAb兔单抗进行Western blot分析。 |
