IFN-α (8C21) Mouse mAb
货号：
3115S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3115S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | IFN-α (8C21) Mouse mAb detects recombinant human interferon-α protein. This antibody does not cross-react with human interferon-β and -γ. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Interferons (IFNs) appear both locally and systematically early after viral infection and participate in limiting the spread of infection. They also affect cell differentiation, growth, surface antigen expression and immunoregulation (1). There are three naturally occurring interferons: α, β and γ. IFN-α is derived from lymphoblastic tissue and has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. Recombinant IFN-α from both natural and synthetic genes binds to a common cell surface receptor and induces antiviral activity in a variety of cell lines. When binding to discrete cell surface receptors on target cells, IFN-α induces rapid changes in Jak/Stat phosphorylation, which initiates the Jak/Stat signaling pathway (2). IFN-α signaling also involves production of DAG without an increased intracellular free calcium concentration and the subsequent activation of calcium-independent isoforms of PKC (β and ε) (3). All IFN-α signaling pathways lead to final alterations of gene expression, which mediate their pleiotropic biologic activities. |
| 存放说明 | -20C |
| 计算分子量 | 19 |
参考图片Western blot analysis of natural human interferon-α proteins at various concentrations, using IFN-α (8C21) Mouse mAb.Western免疫印迹。用IFN-α (8C21) Mouse mAb研究不同浓度的自然状态下人的干扰素-α蛋白。 |
