IL-1β (D4T2D) Rabbit mAb (Mouse Specific)
货号：
12426S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12426S |
| 反应种属 | Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | IL-1β (D4T2D) Rabbit mAb (Mouse Specific) recognizes endogenous levels of total mouse IL-1β protein. This antibody can detect 500 pg of mature recombinant mouse IL-1β. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Interleukin-1β (IL-1β) is a proinflammatory cytokine produced predominantly by activated monocytes and epithelial cells (1). Precursor IL-1β is cleaved by caspase-1 and mature IL-1β is then secreted (1-3). Target cells include macrophages and many other cell types. Signaling by IL-1β involves IL-1β binding to IL-1 accessory protein (IL-1-AcP); the complex then binds to IL-1RI (1,2). Signaling occurs through activation of MAP kinase and NF-κB pathways (1,2). IL-1β also binds to IL-1RII, which lacks an intracellular signaling domain and thereby serves as a high affinity decoy receptor. IL-1β binding to IL-1RI is inhibited by the negative regulator, IL-1R antagonist (IL-1Ra). IL-1Ra binding to IL-1RI does not signal and serves to block IL-1β signaling. IL-1β plays critical roles in the acute phase response and sepsis (1-3). |
| 存放说明 | -20C |
| 计算分子量 | 17,31 |
参考图片Western blot analysis of Mouse Interleukin-1β (mIL-1β) #5204 using IL-1β (D4T2D) Rabbit mAb (Mouse Specific).Westen blot分析Mouse Interleukin-1β (mIL-1β) #5204 ，使用抗体是 IL-1β (D4T2D) Rabbit mAb (Mouse Specific)。 |
Western blot analysis of extracts from Raw 264.7 cells, untreated (-) or LPS-treated (1 μg/ml, overnight; +), using IL-1β (D4T2D) Rabbit mAb (Mouse Specific).Western blot分析Raw264.7细胞的细胞提取物，未处理(-)或LPS处理 (1 μg/ml, 过夜; +)，使用抗体是 IL-1β (D4T2D) Rabbit mAb (Mouse Specific)。 |
