| 货号 | 9699S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | Integrin β1 (D2E5) Rabbit mAb detects endogenous levels of total integrin β1 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:100) |
| 供应商 | CST |
| 背景 | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). The β1 subfamily includes 12 distinct integrin proteins that bind to different extracellular matrix molecules (4). Control of extracellular integrin binding influences cell adhesion and migration, while intracellular signaling messages relayed by the β1 cytoplasmic tail help to regulate cell proliferation, cytoskeletal reorganization, and gene expression (4). Research studies have implicated β1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 115, 135 |
Western blot analysis of extracts from various cell lines using Integrin β1 (D2E5) Rabbit mAb.Western blot分析多种细胞提取物，使用的抗体是Integrin β1 (D2E5) Rabbit mAb。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Integrin β1 (D2E5) Rabbit mAb. 免疫组化分析石蜡包埋人乳腺癌组织，使用的抗体是Integrin β1 (D2E5) Rabbit mAb。 | |
Immunohistochemical analysis of paraffin-embedded human skin using Integrin β1 (D2E5) Rabbit mAb. 免疫组化分析石蜡包埋人皮肤组织，使用的抗体是Integrin β1 (D2E5) Rabbit mAb。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Integrin β1 (D2E5) Rabbit mAb. 免疫组化分析石蜡包埋人肺癌组织，使用的抗体是Integrin β1 (D2E5) Rabbit mAb。 |
