| 货号 | 8568S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | IP3 Receptor 1 (D53A5) Rabbit mAb recognizes endogenous levels of total IP3R1 protein. This antibody may also detect IP3R2 and IP3R3 as the antigen is highly conserved. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3R1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation (1). Four individual receptor subunits, resulting in homo- or hetero-oligomerization of the receptor isoform, form a functional channel (2). Phosphorylation of IP3R1 at Ser1756 by cyclic-AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release (3,4). IP3R1-mediated Ca2+ release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells (5). |
| 存放说明 | -20C |
| 计算分子量 | 320 |
Western blot analysis of extracts from mouse and rat brain using IP3 Receptor 1 (D53A5) Rabbit mAb. 对大鼠和小鼠脑抽提物使用IP3 Receptor 1 (D53A5)兔单克隆抗体进行Western blot分析。 |
