IRP2 (D6E6W) Rabbit mAb
货号：
37135S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 37135S |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Iron regulatory proteins (IRPs; also known as IREBs) are RNA-binding proteins that recognize iron-responsive elements (IREs) and play an important role in maintaining iron homeostasis in mammalian cells. IREs are conserved cis-regulatory hairpin structures located within the 5’ or 3’ untranslated regions (UTRs) of target mRNAs. IRPs inhibit translation when bound to IREs within the 5’ UTR of mRNA encoding for proteins involved in iron storage, export, and utilization. IRP binding to multiple IREs within the 3’ UTR of transferin receptor 1 (TFR1) mRNA prevents its degradation, thereby augmenting translation of TFR1 and increasing iron uptake into cells (1-3). Dysregulation of IRPs has been associated with human cancers (4-6). |
| 存放说明 | -20C |
| 计算分子量 | 105 |
参考图片Western blot analysis of extracts from 293 cells, treated overnight with ammonium iron(III) citrate (FAC; 50 μM) or with deferoxamine mesylate (DFO; 50 μM), using IRP2 (D6E6W) Rabbit mAb. |
