LRP5 (D5G4) Rabbit mAb
货号：
5440S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5440S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | LRP5 (D5G4) Rabbit mAb detects endogenous levels of total LRP5 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain (1). They function as co-receptors for Wnt and are required for the canonical Wnt/β-catenin signaling pathway (2,3). LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5). The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7). Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10). Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling (8-10). |
| 存放说明 | -20C |
| 计算分子量 | 200 |
参考图片Western blot analysis of extracts from HeLa and SW620 cells using LRP5 (D5G4) Rabbit mAb.用LRP5 (D5G4) 兔单抗在western blot实验中检测HeLa和SW620细胞提取物。 |
