LSD1 (1B2E5) Mouse mAb
货号：
4064S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4064S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | LSD1 (1B2E5) Mouse mAb detects endogenous levels of total LSD1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Lysine-specific demethylase 1 (LSD1; also known as AOF2 and BHC110) is a nuclear amine oxidase homolog that acts as a histone demethylase and transcription cofactor (1). Gene activation and repression is specifically regulated by the methylation state of distinct histone protein lysine residues. For example, methylation of histone H3 at Lys4 facilitates transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone methyltransferase complexes (2,3). In contrast, methylation of histone H3 at Lys9 facilitates transcriptional repression by recruiting HP1 (4,5). LSD1 is a component of the CoREST transcriptional co-repressor complex that also contains CoREST, CtBP, HDAC1 and HDAC2. As part of this complex, LSD1 demethylates mono-methyl and di-methyl histone H3 at Lys4 through a FAD-dependent oxidation reaction to facilitate neuronal-specific gene repression in non-neuronal cells (1,6,7). In contrast, LSD1 associates with androgen receptor in human prostate cells to demethylate mono-methyl and di-methyl histone H3 at Lys9 and facilitate androgen receptor-dependent transcriptional activation (8). Therefore, depending on gene context LSD1 can function as either a transcriptional co-repressor or co-activator. LSD1 activity is inhibited by the amine oxidase inhibitors pargyline, deprenyl, clorgyline and tranylcypromine (8). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
参考图片Western blot analysis of cell lysates from HeLa, NIH/3T3 and COS cells, using LSD1 (1B2E5) Mouse mAb. 使用LSD1 (1B2E5) Mouse mAb鼠单抗，免疫印迹(Western blot)分析HeLa、NIH/3T3和COS细胞中LSD1 (1B2E5)的蛋白水平 |
