M-CSF Receptor (E7S2S) Rabbit mAb
货号：
14582S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 14582S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | After initial dimerization and autophosphorylation, the M-CSF receptor undergoes a regulated intramembrane proteolysis (RIP) involving two cleavage events. Extracellular cleavage of this membrane protein results in release of the extracellular domain, while cleavage in the transmembrane region releases the cytoplasmic domain into the cytosol (9). The activated intracellular domain localizes to the nucleus to regulate transcription of specific pro-inflammatory genes (10). Research studies indicate that the processing and down regulation of M-CSF receptor is a continuous process whose rate increases in response to various stimuli, including PMA, LPS, tumor necrosis factor, IL-2, Il-4, and the physiological ligand M-CSF (9). |
| 存放说明 | -20C |
| 计算分子量 | 175 |
参考图片Western blot analysis of extracts from GDM-1 and NKM-1 cells using M-CSF Receptor (E7S2S) Rabbit mAb. |
