Mer (348E6) Mouse mAb
货号：
9178S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 9178S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | Mer (348E6) Mouse mAb detects endogenous levels of Mer proteins. It does not cross-react with other receptor tyrosine kinase family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Mer tyrosine kinase belongs to a receptor tyrosine kinase family with Axl and Tyro-3. This family is characterized by a common N-CAM (neural adhesion molecule)-related extracellular domain and a common ligand, GAS6 (growth arrest-specific protein 6). Mer protein has an apparent molecular weight of 170-210 kDa due to different glycosylation pattern generated in different cell types. Mer can be activated by dimerization and autophosphorylation through ligand binding or homophilic cell-cell interaction mediated by its NCAM-like motif (1). The downstream signaling components of activated Mer include PI3 kinase, PLCγ and MAP kinase (2). Family members are prone to transcriptional regulation and carry out diverse functions including the regulation of cell adhesion, migration, phagocytosis, and survival (3). Mer regulates macrophage activation, promotes apoptotic cell engulfment, and supports platelet aggregation and clot stability in vivo (4). Overexpression of Mer may play a cooperative role in leukemogenesis and may be an effective target for biologically based leukemia/lymphoma therapy (5). |
| 存放说明 | -20C |
| 计算分子量 | 210 |
参考图片Western blot analysis of U937 cell lysate using Mer (348E6) Mouse mAb.用Mer (348E6) Mouse mAb对U937细胞的裂解液进行免疫印迹检测。 |
