MESDC2 (C22F5) Rabbit mAb
货号：
2763S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2763S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | MESDC2 (C22F5) Rabbit mAb detects endogenous levels of total MESDC2 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7 (1). MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6 (2). MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling (3-5). The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass (6). |
| 存放说明 | -20C |
| 计算分子量 | 25, 26 |
参考图片Western blot analysis of extracts from various cell lines using MESDC2 (C22F5) Rabbit mAb.用MESDC2 (C22F5) 兔单抗对多种细胞提取物进行wetern blot分析。 |
