| 货号 | 12551S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P/IF-F |
| 目标/特异性 | mGluR1 (D5H10) Rabbit mAb recognizes endogenous levels of total mGluR1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:200) IF-F (1:800) |
| 供应商 | CST |
| 背景 | Metabotropic glutamate receptor 1 (mGluR1) is a G protein-coupled receptor (GPCR) for the neurotransmitter glutamate in the mammalian brain. Unlike ionotropic receptors, metabotropic receptors do not form an ion channel pore themselves but are indirectly linked to ion channels (1). Both mGluR1 and mGluR5 are coupled to phospholipase C and activate inositol phospholipid metabolism via G protein-mediated mechanisms. Upon phosphatidylinositol activation, the second messenger calcium is released and generates a calcium-activated chloride current. Metabotropic glutamate receptors other than mGluR1 and mGluR5 inhibit adenylate cyclase (1-3). mGluR1 does not share sequence homology with conventional GPCRs (1). mGluR1 forms a homodimer and is linked to synaptic plasticity, as well as long-term potentiation and long-term depression. Furthermore, mGluR1 is a potential therapeutic target for various psychiatric and neurological diseases, including schizophrenia, epilepsy, and Parkinson and Alzheimer diseases (4-6). |
| 存放说明 | -20C |
| 计算分子量 | 145, >300 |
Confocal immunofluorescent analysis of adult mouse cerebellum tissue using mGluR1 (D5H10) Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). 共聚焦免疫荧光分析成年小鼠小脑，使用的抗体是mGluR1 (D5H10) Rabbit mAb兔单抗（绿色）。蓝色伪彩=DRAQ5®＃4084（荧光DNA染料）。 | |
Western blot analysis of extracts from neonatal mouse brain and rat brain using mGluR1 (D5H10) Rabbit mAb. Western blot 检测新生小鼠大脑和大鼠大脑提取物，使用的抗体是 mGluR1 (D5H10) Rabbit mAb兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded rat retina using mGlur1 (D5H10) Rabbit mAb. |
