Microcephalin-1/BRIT1 (D38G5) Rabbit mAb
货号：
4120S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4120S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Microcephalin-1 (MCPH1)/BRIT1 is an early DNA damage response protein named for its mutated state in the human disease primary microcephaly. BRIT1 forms damage-induced nuclear foci, is involved in DNA damage and cell cycle checkpoints as well as regulation of mitosis. BRIT1 function is necessary for DNA damage responses, and the absence of BRIT1 function leads to genome instability. A potential tumor suppressor, BRIT1 expression is reduced in human carcinomas (1-2, reviewed in 3).
BRIT1 colocalizes with other DNA repair proteins (53BP1, MDC1, NBS1, ATM, RPA, and ATR) and is required for their activation (2). BRIT1 likely regulates DNA repair through chromatin remodeling in response to DNA damage, allowing access of repair proteins to DNA (4).微脑磷脂-1 (MCPH1)/BRIT1是一种早期DNA损伤反应蛋白，以其在人类原发性小颅疾病中的突变状态而得名。BRIT1形成的损伤-诱导核灶参与DNA损伤和细胞周期检验点并调节有丝分裂。BRIT1在DNA损伤反应中必不可少，其缺失可以导致基因组不稳定性。作为一个潜在的肿瘤抑制基因，BRIT1在人类癌症中的表达是减少的(回顾1-2, 3)。BRIT1和其它的DNA修复蛋白(53BP1, MDC1, NBS1, ATM, RPA, ATR)共定位而且对于它们的激活时必须的(2)。BRIT1可能是通过响应DAN损伤的染色质重构来调节DNA修复，允许修复蛋白进入DNA(4)。 |
| 存放说明 | -20C |
| 计算分子量 | 100 |
参考图片Western blot analysis of extracts from various cell types using Microcephalin-1/BRIT1 (D38G5) Rabbit mAb.western blot方法检测不同细胞提取物，使用的抗体为Microcephalin-1/BRIT1 (D38G5) Rabbit mAb。 |
