Mnk1 (C4C1) Rabbit mAb
货号：
2195S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2195S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Mnk1 (C4C1) Rabbit mAb detects endogenous levels of total Mnk1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Mitogen-activated protein kinases (MAPKs) are activated by various extracellular signals and play crucial roles in regulating cell proliferation, differentiation, survival, and apoptosis (1). MAPK-interacting kinases (Mnks or MKNKs) are direct downstream substrates of MAPK and were first discovered independently by the work of Fukunaga and Hunter (2) and Waskiewicz and Cooper (3). There are 2 Mnks in human, termed Mnk1 and Mnk2. Both Mnks possess a MAPK-binding domain that allows them to bind to and then to be phosphorylated by Erk and p38. The phosphorylation in the T-loop of Mnks stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF4E) (2,3). eIF4E is a key component of the translational machinery mediating the initiation of translation, but how phosphorylation of eIF4E regulates translation initiation is still under investigation (4). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
参考图片Western blot analysis of extracts from various cell lines using Mnk1 (C4C1) Rabbit mAb. 使用Mnk1 (C4C1) Rabbit mAb兔单抗，免疫印迹（Western blot）分析不同细胞系的提取物。 |
