| 货号 | 39909S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | MRP3/ABCC3 belongs to the super family of ATP-binding cassette (ABC) transporters. It is a member of the MRP subfamily that is expressed in various organs including liver, gallbladder, small intestine, colon, kidney, and adrenal gland (1-3). MRP3 is involved in multi-drug resistance (1). It facilitates the efflux of organic anions including monoanionic bile acid and anti-cancer reagents such as etoposide and paclitaxel from liver and small intestine into blood (4-7). Expression of MRP3 is increased in the cholestatic human and rat liver, suggesting its role in cholehepatic and enterohepatic bile circulation and in protecting liver from toxic bile salts (2,8). MRP3 expression is also upregulated in people with Dubin-Johnson Syndrome (DJS) who lack functional MRP2 in the liver, which implicates the compensatory role of MRP3 in the absence of functional MRP2 (4). |
| 存放说明 | -20C |
| 计算分子量 | 160-220 |
Western blot analysis of extracts from C2C12 and mIMCD-3 cells using MRP3/ABCC3 (D8V8J) Rabbit mAb. | |
Western blot analysis of membrane extracts from human, mouse, and rat liver using MRP3/ABCC3 (D8V8J) Rabbit mAb. | |
Immunoprecipitation of MRP3 from C2C12 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is MRP3/ABCC3 (D8V8J) Rabbit mAb. Western blot analysis was performed using MRP3/ABCC3 (D8V8J) Rabbit mAb. |
