MYH (D13D4) Rabbit mAb
货号：
6248S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6248S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Base excision repair (BER) proteins catalyze the removal of incorrect or damaged bases, including oxidized bases, from DNA. N-glycosylases specific to a given lesion remove the incorrect base as the first step in BER. MYH is the mammalian ortholog of E. coli MutY, a DNA glycosylase that catalyzes the removal of 8-oxoG:A mismatches (1). Several MYH isoforms have been detected in human cells localizing to either the nucleus or the mitochondria (2). MYH interacts with DNA repair proteins and localizes to DNA damage foci after oxidative damage (3). Research studies have shown that mutations in the corresponding MYH gene are associated with human gastric (4) and colorectal (5-7) cancers.碱基切除修复(BER)蛋白能够催化清除DNA中错误的或损坏的碱基，包括被氧化的碱基。BER的第一步是针对特定损伤特异的N-糖基酶清除错误的碱基。MYH是大肠杆菌MutY(一种DNAN-糖基酶，可以催化清除8-O G:A错配)的哺乳动物直接同源蛋白(1)。在人类细胞中已检测到几个分布于细胞核或线粒体的MYH亚型(2)。MYH可以和DNA修复蛋白相互作用并集中在氧化损伤后的DNA损伤位点(3)。相应的MYH基因突变和人类胃癌(4)和结肠癌(5-7)有关。 |
| 存放说明 | -20C |
| 计算分子量 | 55 |
参考图片Western blot analysis of extracts from various cell lines using MYH (D13D4) Rabbit mAb.Western blot方法检测不同细胞提取物，使用的抗体为MYH (D13D4) Rabbit mAb。 |
