Myosin VI (D5Y5A) Rabbit mAb
货号：
13592S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13592S |
| 反应种属 | Human/Dog |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | <p>The myosin family of motor proteins drive ATP-dependent actin-based motility in eukaryotic cells and contain a conserved amino-terminal motor domain (reviewed in 1,2).</p><p>Myosin VI is an unconventional minus-end-directed myosin involved in the transport of vesicles and organelles within the cell, endocytosis, and organelle biogenesis (3-6). The movement of myosin VI and its cargo along actin filaments is unique among myosin family members in its mechanism; its tail domain structure allows it to take larger than predicted steps along the actin filament (reviewed in 1,7).</p><p>Myosin VI has been shown to regulate the polarized delivery of proteins to specialized subcellular locations, including the delivery of EGFR to the leading edge of migrating cells (8), as well as the delivery of specialized axonal proteins in neurons (9). Myosin VI has also been shown to mediate activity of the tumor suppressor p53 during DNA damage (10,11).</p>马达蛋白myosin家族真核细胞中推动ATP-依赖的actin-based运动，myosin家族含有一个保守的氨基末端马达结构域（1,2）。Myosin VI是一个非传统的minus-edn-directedmyosin涉及了囊泡和细胞器的转运，内吞和细胞器生成（3-6）。myosin VI的运动和沿着肌动蛋白丝的cargo在myosin家族成员中是一种独特的机制；它的尾部结构域使其能够采取大于预测的步骤沿着肌动蛋白丝运动（1,7）。Myosin VI也被证明可以调控蛋白的极化分布到特异的亚细胞位置，包括促进EGFR到达迁移细胞的前缘，以及运送神经元中专门的轴突蛋白（9）。Myosin VI也被证明接到了DNA损伤过程中抑癌因子p53的活性（10,11）。 |
| 存放说明 | -20C |
| 计算分子量 | 150 |
参考图片Western blot analysis of extracts from various cell lines using Myosin VI (D5Y5A) Rabbit mAb. 使用Myosin VI (D5Y5A) Rabbit mAb对多种细胞提取物进行western blot分析。 |
