Neuropilin-1 (D62C6) Rabbit mAb
货号：
3725S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3725S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single pass, transmembrane signaling proteins encompassing Plexin A1, A2, A3 and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).Class 3 secreted semaphorin (Sema3A)是多种轴突上的神经生长导向因子。因此，它可以诱导微丝发生戏剧性的再分布和解聚，导致生长锥崩塌。Plexins是单次跨膜信号转导蛋白，包括Plexin A1，A2，A3和A4。Plexins可以与neuropilin-1、neuropilin-2和细胞黏附蛋白L1形成功能性的semaphorin受体（1,2）。GTP酶Rnd1结合Plexin A1的细胞质结构域，触发细胞骨架崩溃。相反，GTP酶RndD阻止Rnd1-介导的Plexin A1的活性和Sema3A所致交感神经轴突的排斥（3）。 |
| 存放说明 | -20C |
| 计算分子量 | 120 |
