NHERF2 (D3A5) Rabbit mAb
货号：
9568S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 9568S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Na+/H+ exchanger regulatory factor 2 (NHERF2) is one of four proteins in the NHERF protein family. It is closely related to NHERF1 and, like NHERF1, contains two PDZ domains and a C-terminal ezrin/radixin/moesin (ERM) binding domain (EBD). Along with the other members of this protein family, NHERF2 is abundantly present in the mammalian small intestine and colon where it plays a central role in trafficking, membrane retention, dimerization, and regulation of ion channels and membrane proteins (1). NHERF2 is a scaffolding protein that recruits membrane proteins to the apical membrane by tethering them to the apical cytoskeleton via its ERM domain (2). It has been shown that the NHERF proteins bind to the Na+/H+ exchanger 3 (NHE3) in the brush border of intestinal epithelial cells. NHE3 accounts for the majority of neutral NaCl absorbtion and NHERF proteins play an essential role in NHE3 regulation (3). |
| 存放说明 | -20C |
| 计算分子量 | 46 |
参考图片Western blot analysis of extracts from MCF7 and T-47D cells using NHERF2 (D3A5) Rabbit mAb. |
