Notch3 (8G5) Rat mAb
货号：
3446S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3446S |
| 反应种属 | Human |
| 来源宿主 | Rat |
| 应用 | W |
| 目标/特异性 | Notch3 (8G5) Rat mAb detects endogenous levels of total notch3 protein. It recognizes the full-length (270 kDa) and the extracellular truncated fragment containing a short extracellular region, the transmembrane domain and the intracellular region (90 kDa). |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Notch1 is a transmembrane protein functioning in development and the determination of cell fate (1). During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain (2). Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1743 and Val1744 (3,4). The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. |
| 存放说明 | -20C |
| 计算分子量 | 90, 270 |
参考图片Western blot analysis of extracts from HBP-ALL and A204 cells using Notch3 (8G5) Rat mAb. Full-length (FL) and cleaved notch3 proteins are indicated. 使用Notch3 (8G5) Rat mAb大鼠单抗对HBP-ALL和A204细胞提取物进行western blot分析。notch3的全长蛋白（FL）和剪切后如图所示。 |
