NRMT (D9D6P) Rabbit mAb
货号：
13432S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13432S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | N-terminal RCC1 methyltransferase (NRMT), formerly known as methyltransferase-like protein 11A (METTL11A), is a member of the methyltransferase 11 family of proteins and is the first α-N-methyltransferase to be discovered in humans (1-3). Amino-terminal methylation of free α-amino groups is a post-translational modification where an initiating Met residue is cleaved and the exposed α–amino group is mono-, di-, or trimethylated by NRMT (4). NRMT methylates proteins containing an amino-terminal Met-X-Pro-Lys motif, where X is an alanine, proline, or serine residue (4). Substrates of NRMT include the Ran guanine nucleotide-exchange factor (RCC1), SET/TAF-1/PHAP-II, retinoblastoma (Rb), and CENP-B (3-6). α-N-methylation of RCC1 is required for efficient binding to chromatin, securing normal bipolar spindle formation and chromosome segregation (3,5). α-N-methylation of CENP-B also appears to regulate CENP-B binding to centromeric DNA (6).N末端RCC1甲基转移酶（NRMT），最初被认为是甲基转移酶样蛋白11A(METTL11A),是甲基转移酶11家族蛋白的一员，也是人体最早被发现的α-N-甲基转移酶（1-3）。free α-amino家族的氨基端甲基转移是一个翻译后修饰过程，其间Met残基被脱离，然后暴露的α-amino家族被NRMT单甲基化，双甲基化或多甲基化（4）。NRMT甲基化含有氨基端Met-X-Pro-Lys基序的蛋白，其中X可以是丙氨酸、脯氨酸、或丝氨酸残基(4)。NRMT的底物包括Ran 鸟嘌呤核苷酸转移因子(RCC1), SET/TAF-1/PHAP-II, 成视网膜细胞瘤(Rb),和 CENP-B (3-6). RCC1的α-N-甲基化对于与染色质的结合，正常双极纺锤体形成和染色质分离都是必须的（3-5）。CENP-B的α-N-甲基化也能调控CENP-B和着丝粒DNA的结合（6）。 |
| 存放说明 | -20C |
| 计算分子量 | 25 |
参考图片Western blot analysis of extracts from various cell lines using NRMT (D9D6P) Rabbit mAb.使用NRMT (D9D6P) Rabbit mAb对多种细胞提取物进行western blot分析。 |
