OTX2 (D7Y3J) Rabbit mAb
货号：
11943S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11943S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | OTX2 (D7Y3J) Rabbit mAb recognizes endogenous levels of total OTX2 protein. This antibody recognizes both known human isoforms. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Orthodenticle homeobox 2 (OTX2) belongs to the bicoid subfamily of paired-box, homeodomain-containing transcription factors. OTX2 is a critically important neuronal transcription factor that functions to regulate the expression of cell cycle genes controlling proliferation and differentiation of neural progenitor cells (1-3). In addition to its neuronal development functions, it has been reported that OTX2 can function in a non-cell autonomous manner to promote survival of damaged retinal ganglion cells (4). OTX2 has also been shown to influence the susceptibility of post-mitotic neurons to toxic insult or physiological stress (3). Notably, aberrant expression of OTX2 has been strongly linked with neuronal tumor development. For example, research studies have found OTX2 is overexpressed in many medulloblastoma cell lines, and both overexpression and gene amplification were reported in a subset of primary medulloblastomas (5). In vitro studies support these observations, as targeted alterations in OTX2 expression directly affected both proliferation and senescence of medulloblastoma cell lines (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 31, 33 |
参考图片Western blot analysis of extracts from Y79, D283 Med, and WERI-Rb-1 cells using OTX2 (D7Y3J) Rabbit mAb. 使用OTX2 (D7Y3J)Rabbit mAb对Y79，D283Med和WERI-Rb-1细胞进行western blot分析。 |
