p47phox (D21F6) Rabbit mAb
货号：
4301S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4301S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | p47phox (D21F6) Rabbit mAb detects endogenous levels of total p47phox protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558 (1). Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease (2-4). Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 47 |
参考图片Western blot analysis of extracts from Ramos and RL cells using p47phox (D21F6) Rabbit mAb.Western免疫印迹。用p47phox (D21F6) Rabbit mAb研究Ramos和RL 细胞的细胞提取液。 |
