PAI-1 (D9C4) Rabbit mAb
货号：
11907S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11907S |
| 反应种属 | Human/Mouse/Rat/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | PAI-1 (D9C4) Rabbit mAb recognizes endogenous levels of total PAI-1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | PAI-1 is a secreted protein that belongs to the serine proteinase inhibitor (serpin) superfamily. It inhibits urokinase and tissue plasminogen activators (uPA and tPA) and thus, reduces the conversion of inactive plasminogen to plasmin (1). PAI-1 regulates fibrinolysis and plays an important role in vessel patency and tissue remodeling. Secreted PAI-1 interacts with the extracellular matrix (ECM) component vitronectin, thereby modulating cell-ECM interactions (2,3). PAI-1 is expressed in a variety of tissues with higher expression in liver, vascular endothelial cells, platelets, macrophages, and adipose tissue (1). Increased levels of PAI-1 are associated with deep vein thrombosis (4). Defects in PAI-1 cause plasminogen activator inhibitor-1 deficiency (PAI-1D), which is characterized by increased bleeding after injury or surgery (5). Research studies have shown that high levels of PAI-1 are associated with obesity, aging, insulin resistance, and type 2 diabetes (6-8). PAI-1 is transcriptionally regulated by TGF-β and mediates TGF-β-induced inhibition of cell migration and invasion in cancer cells (9). Studies have shown PAI-1 to be also involved in fibrosis (10). |
| 存放说明 | -20C |
| 计算分子量 | 48 |
参考图片Western blot analysis of extracts from COS-7 and HUVEC cells using PAI-1 (D9C4) Rabbit mAb.Western blot分析COS-7和HUVEC细胞提取物，采用的抗体是PAI-1 (D9C4) Rabbit mAb。 |
Immunoprecipitation of PAI-1 from COS-7 cell extracts using Normal Rabbit IgG #2729 (lane 2) or PAI-1 (D9C4) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using PAI-1 (D9C4) Rabbit mAb. 免疫沉淀分析 COS-7细胞提取物，采用的抗体是Normal Rabbit IgG #2729 (lane 2) or PAI-1 (D9C4) Rabbit mAb (lane 3)。Lane 1为10%的Input。Western blot分析采用的抗体是PAI-1 (D9C4) Rabbit mAb。 |
