PANK4 (D6J4R) Rabbit mAb
货号：
12665S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12665S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PANK4 (D6J4R) Rabbit mAb recognizes endogenous levels of total PANK4 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Panthothenate kinase (PANK) is an enzyme that is responsible for catalyzing the first step in coenzyme A (CoA) synthesis (1-4). There are four human PANK genes (PANK1-4) (1-4). PANK4 is ubiquitously expressed, but higher expression levels are observed in muscle (1,2). PANK4 expression is elevated in rat skeletal muscle under high glucose conditions (2). There is evidence that rat PANK4 colocalizes with pyruvate kinase M2 (PKM2) in vitro (2). PANK4 may also play a protective role in beta-cell apoptosis by lowering the levels of pro-caspase-9 (3). Research studies have shown that mutations in the PANK2 gene are associated with Neurodegeneration with Brain Iron Accumulation (NBIA), formerly known as Hallervorden-Spatz syndrome (1,4). Expression of hPANK4 in a Drosophila model of NBIA rescues the phenotype with the exception of infertility (4). |
| 存放说明 | -20C |
| 计算分子量 | 82 |
参考图片Western blot analysis of extracts from various cell lines using PANK4 (D6J4R) Rabbit mAb. Western blot 检测多种细胞系提取物，使用抗体为PANK4 (D6J4R) Rabbit mAb兔单抗。 |
