PBEF/NAMPT (D7V5J) Rabbit mAb
货号：
86634S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 86634S |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:200) |
性能| 供应商 | CST |
| 背景 | Nicotinamide phosphoribosyltransferase (NAMPT; also known as Pre-B cell-enhancing factor PBEF) catalyzes the synthesis of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosylpyrophosphate (PRPP), the rate-limiting step in the NAD biosynthesis pathway starting from nicotinamide (1,2). NAD biosynthesis mediated by NAMPT plays a critical role in glucose-stimulated insulin secretion in pancreatic beta cells (3). Both NAMPT inhibitors and activators have been sought for clinical applications (4,5). NAMPT has intra- and extracellular forms (iNAMPT and eNAMPT), and deacetylation of iNAMPT by SIRT1 promotes eNAMPT secretion through a nonclassical secretory pathway (3,6). eNAMPT, independent of its enzymatic activity, can induce epithelial-to-mesenchymal transition in mammary epithelial cells and promote monocyte differentiation into a tumor-supporting M2 macrophage (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 52 |
参考图片Western blot analysis of extracts from HeLa, HT-1080, and DLD-1 cells using PBEF/NAMPT (D7V5J) Rabbit mAb. |
