| 货号 | 3820S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | PDHK1 (C47H1) Rabbit mAb detects endogenous levels of total PDHK1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Pyruvate generated from glycolysis is converted to acetyl-CoA by pyruvate dehydrogenase (PDH) under normoxia (1-3). This is a critical link between glycolysis and the TCA cycle (3). PDH activity is regulated by phosphorylation and dephosphorylation (3). Pyruvate dehydrogenase kinase (PDHK) phosphorylates PDH and inactivates it, whereas dephosphorylation of PDH is carried out by pyruvate dehydrogenase phosphatase to generate the active form (3). Hypoxia can directly induce pyruvate dehydrogenase kinase 1 (PDHK1) expression, which results in inactivation of PDH and the TCA cycle and subsequent suppression of metabolism (4). |
| 存放说明 | -20C |
| 计算分子量 | 47 |
Western blot analysis of extracts from various cell types using PDHK1 (C47H1) Rabbit mAb. Wetern blot检测多种细胞提取物，所用抗体为PDHK1 (C47H1) Rabbit mAb兔单抗。 |
