Pellino-1 (D2Z4F) Rabbit mAb
货号：
31474S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 31474S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Pellino-1 (PELI1) is an E3 ubiquitin ligase that regulates activation of various immune pathways in different contexts and cell types (1). Pellino-1 controls NFκB activation downstream of the interleukin-1 receptor and TLRs through association with and ubiquitination of IRAK1 (1-4). Pellino-1 was also demonstrated to regulate the NFκB pathway in T cells by targeting c-Rel for degradation, thereby enabling suppression by regulatory T cells, maintaining peripheral tolerance, and preventing autoimmunity in mice (5). Finally, in experimental autoimmune encephalomyelitis (EAE), the mouse model of multiple sclerosis, Pellino-1 contributes to inflammation by promoting degradation of Traf3 leading to induction of chemokines and proinflammatory cytokines (6). |
| 存放说明 | -20C |
| 计算分子量 | 47 |
参考图片Western blot analysis of extracts from various cell lines using Pellino-1 (D2Z4F) Rabbit mAb. |
Western blot analysis of 293T cells, mock tranfected (-) or transfected with a construct expressing full-length human Myc/DDK-tagged Pellino-1 (hPellino-1-Myc/DDK; +), using Pellino-1 (D2Z4F) Rabbit mAb. |
