PERK (C33E10) Rabbit mAb
货号：
3192S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3192S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PERK (C33E10) Rabbit mAb detects endogenous levels of total PERK protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status. |
| 存放说明 | -20C |
| 计算分子量 | 140 |
参考图片Western blot analysis of extracts from various cell types using PERK (C33E10) Rabbit mAb. 对多个细胞系使用PERK (C33E10) Rabbit mAb兔单抗进行Western blot分析。 |
