| 货号 | 5683S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 目标/特异性 | PERK (D11A8) Rabbit mAb recognizes endogenous levels of total PERK protein. Staining of red blood cells has been observed. The specificity of this staining is unknown. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:2000) |
| 供应商 | CST |
| 背景 | PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status. |
| 存放说明 | -20C |
| 计算分子量 | 140 |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using PERK (D11A8) Rabbit mAb. 对石蜡包埋的人乳腺癌使用PERK (D11A8) Rabbit mAb兔单抗进行免疫组化分析。 | |
Western blot analysis of extracts from various cell lines using PERK (D11A8) Rabbit mAb. 对多个细胞系使用PERK (D11A8) Rabbit mAb兔单抗进行Western blot分析。 |
