PGC-1α (3G6) Rabbit mAb
货号：
2178S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2178S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PGC-1α (3G6) Rabbit mAb detects transfected levels of total PGC-1α protein. This antibody does not cross-react with PGC-1β or other related proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | PPARγ coactivator-1α (PGC-1α) was originally identified as a transcriptional coactivator whose expression closely correlated with adaptive thermogenesis following exposure to cold temperatures (1). Named for its association with the nuclear receptor peroxisome-proliferator activated receptor (PPARγ), PGC-1α interacts with a diverse array of transcription factors to regulate numerous aspects of cell physiology (2). PGC-1α helps to regulate cell processes important in adaptive thermogenesis and energy metabolism, including the related functions of glucose uptake, gluconeogenesis, insulin secretion, and mitochondrial biogenesis (3). Long thought to be a potential therapeutic target for the treatment of type II diabetes, obesity, cardiomyopathy, or other metabolic disorders (reviewed in 4), a recent functional survey found no obvious differences in PPARγ activity associated with recognized PGC-1α variants (5). |
| 存放说明 | -20C |
| 计算分子量 | 130 |
参考图片Western blot analysis of extracts from 293T cells, either mock transfected (-) or transfected with a construct expressing full-length Myc-DDK-tagged human wild-type PGC-1α (+), using PGC-1α (3G6) Rabbit mAb. 对293T细胞提取液，mock转染(-)或转染全长Myc-DDK标签的人野生型PGC-1α表达载体(+)，使用PGC-1α (3G6) Rabbit mAb兔单抗进行Western blot分析。 |
