| 货号 | 25430S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human/Mouse/Rat/Moneky |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | PSMD2 (D6W7G) Rabbit mAb recognizes endogenous levels of total PSMD2 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Regulatory particle non-ATPase 1 (RPN1, PSMD2) is a subunit of the 19S/PA700 regulatory particle base subcomplex. The PSMD2 protein acts as part of the scaffold for assembly of the 19S/PA700 RP base subcomplex (3). Research studies demonstrate that PSMD2 binds the intracellular domain of type I TNF receptor, indicating that the 26S proteasome may play a role in the TNF signaling pathway (4,5). PSMD2 expression correlates with poor prognosis in lung cancer patients, and induced inhibition of PSMD2 results in decreased proteasome activity and increased apoptosis in lung cancer cells (6). |
| 存放说明 | -20C |
| 计算分子量 | 97 |
| 参考文献 | 1 . Finley, D. (2009) Annu Rev Biochem 78, 477-513. 2 . Lee, M.J. et al. (2011) Mol Cell Proteomics 10, R110.003871. 3 . Rosenzweig, R. et al. (2008) Nat Struct Mol Biol 15, 573-80. 4 . Tsurumi, C. et al. (1996) Eur J Biochem 239, 912-21. 5 . Dunbar, J.D. et al. (1997) J Immunol 158, 4252-9. 6 . Matsuyama, Y. et al. (2011) Mol Carcinog 50, 301-9. |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human PSMD2 protein (hPSMD2-Myc/DDK; +), using PSMD2 (D6W7G) Rabbit mAb. | |
Western blot analysis of extracts from various cell lines using PSMD2 (D6W7G) Rabbit mAb. |
