PI3 Kinase p101 (D32A5) Rabbit mAb
货号：
5569S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5569S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PI3 Kinase p101 (D32A5) Rabbit mAb recognizes endogenous levels of total PI3 Kinase p101 protein. This antibody also detects a strong background band of unknown origin between 50-60 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival (1). PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN (2). PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit. Various isoforms of the catalytic subunit (p110α, p110β, p110γ, and p110δ) have been isolated, and the regulatory subunits that associate with p110α, p110β, and p110δ are p85α and p85β (3). In contrast, p110γ associates with a p101 regulatory subunit that is unrelated to p85. Furthermore, p110γ is activated by βγ subunits of heterotrimeric G proteins (4).The p101 regulatory subunit binds to Gβγ, released from heterotrimeric G proteins, and recruits bound p110γ catalytic subunit to the plasma membrane, which is required for GPCR-induced PI3Kγ activity (5). |
| 存放说明 | -20C |
| 计算分子量 | 101 |
参考图片Western blot analysis of extracts from Raw 264.7 and Jurkat cells using PI3 Kinase p101 (D32A5) Rabbit mAb. Western blot 分析Raw 264.7 和 Jurkat细胞提取物，所用抗体为PI3 Kinase p101 (D32A5) Rabbit mAb兔单抗。 |
