PIAS4 (D2F12) Rabbit mAb
货号：
4392S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4392S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PIAS4 (D2F12) Rabbit mAb detects endogenous levels of total PIAS4 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The PIAS (protein inhibitor of activated Stat) proteins, which include PIAS1, PIAS3, PIASx, and PIASy, were originally characterized based on their interaction with the Stat family of transcription factors (1,2). PIAS1, PIAS3, and PIASx interact with and repress Stat1, Stat3, and Stat4, respectively (1-3). Deletion of PIAS1 leads to inhibition of interferon-inducible genes and increased protection against infection (4). The PIAS family contains a conserved RING domain that has been linked to a function as a SUMO (small ubiquitin-related modifier) ligase, coupling the SUMO conjugating enzyme Ubc9 with its substrate proteins (5,6). Numerous studies have now shown that PIAS family members can regulate the activity of transcription factors through distinct mechanisms, including NF-κB (7,8), c-Jun, p53 (5,9), Oct-4 (11), and Smads (11,12). The activity of PIAS1 is regulated by both phosphorylation and arginine methylation. Inflammatory stimuli can induce IKK-mediated phosphorylation of PIAS1 at Ser90, which is required for its activity (13). In addition PRMT1 induces arginine methylation of PIAS1 at Arg303 following interferon treatment and is associated with its repressive activity on Stat1 (14). |
| 存放说明 | -20C |
| 计算分子量 | 75 |
参考图片Western blot analysis of extracts from 293 and CCRF-CEM cells using PIAS4 (D2F12) Rabbit mAb.Western免疫印迹。用PIAS4 (D2F12) Rabbit mAb研究293 和CCRF-CEM 细胞的细胞提取液。 |
