PINCH (5G7) Mouse mAb
货号：
11890S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11890S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | PINCH (5G7) Mouse mAb recognizes endogenous levels of total PINCH protein. The antibody recognizes a protein of unknown origin at 80 kDa in some cell lines. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The extracellular matrix (ECM) is a complex structure of secreted macromolecules surrounding mammalian organs and tissues. Controlled interactions between cells and the ECM are important in proliferation, migration, survival, polarity, and differentiation. Cells contact the ECM primarily through focal adhesion complexes, which contain integrins, as well as multiple adaptor and signaling proteins (1). The ILK/PINCH/Parvin (IPP) adaptor complex acts at the interface of the integrin/actin connection to regulate formation of focal adhesions and integrin signaling. Roles for IPP proteins outside of the IPP complex have been proposed, including regulation of gene expression (2,3).
PINCH, also known as LIMS1, has been shown to function as a specific regulator of gene expression in glomerular podocytes in response to TGF-β1 (4). Researchers have shown that PINCH is highly expressed in some human tumors, and that PINCH can promote resistance to ionizing radiation through activation of Akt (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
参考图片Western blot analysis of extracts from various cell lines using PINCH (5G7) Mouse mAb.Western blot检测多种细胞提取物，使用的抗体是 PINCH (5G7) Mouse mAb。 |
