PKG-1 (C8A4) Rabbit mAb
货号：
3248S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3248S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PKG-1 (C8A4) Rabbit mAb detects endogenous levels of total PKG-1 protein, including both α and β isoforms. The antibody does not cross-react with PKG-2. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Cyclic GMP-dependent kinases (cGK/PKG) belong to the AGC family of serine/threonine protein kinases. In mammals, two genes encode PKG-1 and PKG-2. Alternative PKG-1 splicing yields α and β isoforms, which display tissue-specific expression patterns in humans (1). All PKG family members are activated by increased cellular cGMP, which binds to the enzymes regulatory domain inducing a conformational change and leading to enzyme activation. cGMP levels are increased through the activation of guanylyl cyclases, a process known to occur in part through nitric oxide (NO) signaling (2).
In addition to well established roles in platelet activation and smooth muscle relaxation (3), PKG signaling is important in many biological processes including cardiac contractility, axon guidance, bone growth, contraction of intestinal smooth muscle and erectile dysfunction (4). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
参考图片Western blot analysis of extracts from various cell and tissue types using PKG-1 (C8A4) Rabbit mAb. 使用PKG-1 (C8A4) Rabbit mAb，免疫印迹（Western Blot）分析不同细胞和组织中PKG-1蛋白水平。 |
