| 货号 | 5658S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Plexin A2 (D42B5) Rabbit mAb detects endogenous levels of total Plexin A2 protein. This antibody also cross-reacts with unidentified proteins at various molecular weights. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).Sema6A is also a ligand for Plexin A2. Both Sema6A and Plexin A2 knock-out mice have a granule cell migration defect, where cells remain in the molecular layer. Furthermore, Plexin A2 also controls nucleus—centrosome coupling which modulates cell migration (4). |
| 存放说明 | -20C |
| 计算分子量 | 212 |
Western blot analysis of extracts from mouse and rat brain tissue using Plexin A2 (D42B5) Rabbit mAb. Western blot分析小鼠和大鼠脑组织，使用的抗体是Plexin A2 (D42B5) Rabbit mAb 兔单抗。 |
