| 货号 | 5512S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Plexin A3 (D2G12) Rabbit mAb detects endogenous levels of total Plexin A3 protein. Plexin A3 (D2G12) Rabbit mAb may cross-react with other family members. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).Both Plexin A3 and A4 mediate the responses to class 3 semaphorins in sensory and sympathetic neurons. In particular, Plexin A4 is responsible for signaling of Sema 3A via neuropilin-1, while Plexin A3 is responsible for signaling of Sema 3F via neuropilin-2 (4). |
| 存放说明 | -20C |
| 计算分子量 | 207 |
Western blot analysis of extracts from human cerebellum, A204 and MCF-7 cells using Plexin A3 (D2G12) Rabbit mAb. Western blot分析人小脑、A204和MCF-7细胞提取物，使用的抗体是Plexin A3 (D2G12) Rabbit mAb 兔单抗。 |
